The School of Computing and Informatics was established in 2011. It emanated from the then department of Computer Science and Technology that was housed in the then faculty of Science.

The School currently houses two academic departments namely, Department of Computer Science and Department of Information Technology. It also houses one semi-academic unit known as Information Technology Enterprise Center (ITEC) which serves as a business / industrial interface between the School and outside world.  ITEC, currently located at the Kisumu Campus, is the successor of the then Maseno Information Technology Centre (MITC).

Computing, information and electronic communication technologies form the engine that powers the most competitive economies of the world. This important consideration drove Maseno University into incorporating the teaching of Information Technology (IT) into all her undergraduate degree programmes in 2003. Consequently, the University currently produces graduates who are sought-after and are playing leading roles in virtually all the sectors of the Kenyan economy and beyond.

The School has an approximate student population of one thousand that is being served by thirty academic staff.